Avila Therapeutics
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Transforming the treatment of human disease through protein silencing

Avila Therapeutics™
Covalent Drugs: Bonding to Targets, Silencing the Disease

Avila Therapeutics will treat human diseases using a remarkably powerful therapeutic approach called ‘protein silencing.’ Using our Avilomics™ platform, we generate covalent drugs that strongly and resiliently bond to specific disease-causing proteins, thereby “silencing” them and eradicating the corresponding disease. Avila’s novel covalent drugs have the potential to improve patient outcomes in a fundamentally new way, and Avila is rapidly developing these therapies for a number of diseases, including viral infections, cancers and autoimmune diseases.

Protein Silencing Animation
Part 1: An Introduction to Covalent Drugs
Part 2: Unique Benefits of Covalent Drugs

 

11/02/09
Avila Presents Preclinical Data on its Novel, Orally-Available Protease Inhibitor, AVL-181, Demonstrating Viral Clearance of Hepatitis C Virus in Preclinical Models

10/5/09
Avila Presents Preclinical Data on its Novel, Orally-Available, Pan-Genotype Protease Inhibitor, AVL-181, Demonstrating Protein Silencing of Hepatitis C Virus

9/25/09
EP Vantage: Avila covalent drugs looking highly attractive

7/28/09
BioWorld: Avila Raises $30M, Pulls Down $200M Deal with Novartis Fund

7/27/09
Avila Therapeutics, Inc. Closes $30 Million Series B Financing

7/27/09
Avila Therapeutics Announces Agreement with Novartis to Develop Novel Covalent Drug Candidate

5/15/09
Avila Therapeutics Appoints Katrine S. Bosley as Company’s First CEO

4/25/09
Avila Presents Preclinical Data on a Novel, Orally-Available, Protease Inhibitor, AVL181, for Hepatitis C Infection at EASL 2009 Meeting

4/21/09
Avila Presents Data on Novel, Orally-Available, Covalent Drugs Targeting Btk and ErbB Receptors, and Innovative Translation Technology, at Annual AACR Meeting